Nucleosomes act
as a barrier in nuclear processes, such as DNA transcription, replication, and
repair. Facilitates chromatin transcription (FACT) plays essential roles in
nucleosome dynamics during these processes.
Two different
mechanisms so far have been proposed for nucleosome reorganization by FACT.
However, these interpretations have left some unsolved
problems in terms of FACTmediated eviction and exchange of histones within
nucleosome.
Most recently, we
have proposed the integrated reorganization mechanism, in which FACT retains
nucleosome in transiently loosened structures. This accessible structure allows
us to explain most reasonably about how FACT directs further disruption of
nucleosome and histone replacement in concert with other factors.
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