The ability of
Hsp90 to activate a disparate clientele implicates this chaperone
in diverse biological processes. To accommodate such varied roles, Hsp90
requires a variety of regulatory mechanisms that are coordinated in order to
modulate its activity appropriately.
Amongst these,
the master-regulator heat shock factor 1 (HSF1) is critically important in
upregulating Hsp90 during stress, but is also responsible, through interaction
with specific transcription factors (such as STAT1 and Strap/p300) for the
integration of a variety of biological signals that ultimately modulate Hsp90
expression.
Additionally,
transcription factors, such as STAT1, STAT3 (including STAT1-STAT3 oligomers),
NF-IL6, and NF-kB, are known to influence Hsp90 expression directly.
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