Negative Involvement of the Working Environment in the Occurrence of Cognitive Disorders

Most of cognitive disorders are masked by symptoms they have in common with many others human illnesses like influenza and headache. Prevention appears unavoidable and, monitoring their evolution may help to reduce incidence of major brains disorders.

In this goal, an observational research was leaded in a call center sample, to evaluate the distribution and the evolution of cognitive impairments and mood disorders.

Demographic and clinical data, insomnia and sleeps disorders, drugs usage associated with cognitive decline, gender, level of education, family medical history, depression and anxiety were collected. Correlation was found between time of work and cognitive decline, depression and time of work, sleep disorders and cognitive complaints.

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Environmental Bioremediation of Industrial Effluent

Deaden the use of microorganisms or condense the concentration of hazardous waste contaminated plant is called biodegradation.

Biological cleaning systems have a variety of applications such as decontamination of contaminated areas such as water, soil, sludge and flows.

Rapid industrialization, urbanization, intensive agriculture and other human activities have led to land degradation, pollution and decrease crop productivity in all sectors of agriculture.

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Regulatory Mechanisms of Hsp90

The ability of Hsp90 to activate a disparate clientele implicates this chaperone in diverse biological processes. To accommodate such varied roles, Hsp90 requires a variety ofregulatory mechanisms that are coordinated in order to modulate its activityappropriately.

Hsp90

Amongst these, the master-regulator heat shock factor 1 (HSF1) is critically important in upregulating Hsp90 during stress, but is also responsible, through interaction with specific transcription factors (such as STAT1 and Strap/p300) for the integration of a variety of biological signals that ultimately modulate Hsp90 expression. Additionally, transcription factors, such as STAT1, STAT3 (including STAT1-STAT3 oligomers), NF-IL6, and NF-kB, are known to influence Hsp90 expression directly. Read more>>>>

Pathogenic Aspects of Genito-Urinary Tuberculosis in Males and Females

Tuberculosis (TB), one of the deadliest diseases is creating an impediment in human health world widely. Mycobacterium tuberculosis causespulmonary TB, which later on shifts its impact on other body organs rather than only lungs. So here bacilli generate the extra-pulmonary form of TB.

Genito-Urinary Tuberculosis

Genito-urinary form of EPTB is world’s second most risky form of TB which brings ill effects on reproductive health of population. GUTB is much more destructive which affects males and females both but in males, susceptibility towards disease is more. Now-a-days infertility is the major concern in both males and females which arises due to the infection of bacilli in genital organs. Some frequent symptoms like dysuria, pyuria, abdominal pain, hematuria may be observed and fever, weight loss, anorexia are less common. GUTB can be diagnosed on the basis of various culture studies and also through the radiological imaging by ultra sound, pelvic MRI etc. PCR is also best method for the diagnosis of the bacilli of MTB in urine and the ideal result can be obtained within 24-48 hours. Surgery is also preferred if kidney or epididymis is infected with the bacilli. Read more>>>>>

A Model for Biological Transport - Flow of Fluid between Dilating and Squeezing Channel

Mohyud-Din et al., studied the laminar flow dynamics of an incompressible viscous fluid inside a semi-infinite rectangular domain; the rectangular confinement is bound by twomobile porous walls that allow the entry or exit of the fluid during successive expansions and contractions.

The authors applied the Variation of Parameters Method (VPM) for tackling the problem; from the results it was clear that VPM can be successfully applied to nonlinear equations. The results from the work bore a remarkable resemblance to the pre-existing numerical solutions. In biological fluid transport, the flow through expanding and contracting porous vessels is a common phenomenon. Its vital importance in many parts of synthetic respiratory systems, artificial circulatory systems and several industrial processes is also an established fact. Therefore, its study has attracted many researchers from all over the world and they have contributed their work in this regard. Read more>>>>>>

Study Body Composition of Adolescent Girls

Nutritional status of individuals or populations and measurements of food and nutrient intake and evaluation of nutrition-related health indicators is aspect of study nutritional anthropometry.

The use of nutritional assessment has increased importance in recent years because of our greater knowledge of the nutritional status and health. It refers not only to inadequate dietary intake or undernutrition but also to over- nutrition characterized by obesity and its associated co-morbidities such as diabetes mellitus, cardiovascular disease, hypertension and stroke, osteoporosis, and some form of cancer as well.

Malnutrition is a “pathological state resulting from a relative or absolute deficiency or excess of one or more essential nutrients”. Sample size: For this study 1009 adolescent’s girls are chosen as subjects for this study.

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A New Strategy and System for the Ex-Vivo Testicle Perfusion and Cryopreservation

Testicular cryopreservation aims at the preservation of fertility in children and prepubertal boys, subjected to gonadotoxic anti-cancer therapy, hematopoieticstem cells transplantation and other reasons of intensive chemotherapy.

Cryopreservation

Further indications could differ from country to another, based on the available medical regulations. Testicular cryopreservation can be performed using the slow freezing technique, where a programmable controlled temperature change can be applied, or the Vitrification technique, where the testicular tissue is equilibrated with suitable concentrations of cryoprotectants and directly plunged into liquid nitrogen. Recently, the technique of cryopreservation has been tried with animals and humans, applying both slow freezing and Vitrification techniques, with the results of Vitrification are comparable to those of slow freezing. Read more>>>>>

ROR1 is an Intriguing Target for Cancer Therapy

Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) is an oncofetal protein and has gained attention in cancer therapy since its initial discovery as a relatively specific surface antigen on B cell chronic lymphocytic leukemia (CLL) in 2008. The list of cancer types with ROR1 expression keeps growing, comprising, among others,malignant melanoma, breast cancer, and prostate cancer. It has been shown that ROR1 mediates several oncogenic pathways in a cancer type- and context-dependent manner.

There are several ways to target ROR1 molecule, some of which have been in preclinical and clinical trials. We briefly summarize the oncogenic signaling pathways related to ROR1, as well as the update on ROR1-targeted therapies. ROR1 is transmembrane receptor tyrosine kinase-like protein that is mainly expressed in cells during embryogenesis; however, ROR1 has been shown to re-express in several cancer types. At the amino terminus of ROR1 is an extracellular immunoglobulin-like domain, a cysteine-rich domain, also named the Frizzled domain, and a highly folded, cysteine-rich Kringle transmembrane domain.

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Pressure Effect on the Folding of G-Quadruplex DNA Modified with Hexaethylene Glycol

Nucleic acids (DNA and RNA) are polymers that can adopt a variety of structures stabilized via base pairing. Watson-Crick type hydrogen bonding results in the canonical double helixbetween two complementary strands. Relying on this simple law of self-assembly, nucleic acids has been used as a drug and nanomaterials.

G-Quadruplex DNA

Hoogsteen-type hydrogen bonding permits formation of non-canonical structures of nucleic acids. In particular, guanine-quadruplex (G-quadruplex) DNA structures are stabilized by guanine quartets that interact via Hoogsteen base pairing. This tetraplex structure coordinates metal ions such as Na+ and K+, which contribute the structural stability. Furthermore, the stabilities of G-quadruplexes are increased in conditions of molecular crowding. These properties indicate that changes in molecular environment can regulate the folding and unfolding of G-quadruplex structures, and external chemical and physical stimuli are useful for control of structures of nucleic acid-based drugs and nanomachines.

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