Embryonic stem cells
(ESC’s) are a set of pluripotent cells unique in character which are obtained
from preimplantation blastocyst stage embryos.
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Induced Pluripotent Stem Cells
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They can either undergo
asymmetric divisions whereby they either duplicate themselves or differentiate
into another cell type. Adult stem cells on the other hand are undifferentiated
cells found around differentiated cells in a tissue or an organ. While they are
multipotent they can differentiate into a limited number of cell types. ESC’s
can proliferate indefinitely in an undifferentiated state. They express
specific markers or characteristics like stage specific embryonic antigens,
enzymatic activities like alkaline phosphatase and telomerase, ’stemness’ genes
which are rapidly downregulated upon differentiation including Octamer (Oct 4)
and Nano g.
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