Monday 26 June 2017

Endothelial Dysfunction an Evolving Target in Diabetic Nephropathy

Diabetic nephropathy (DN) is a leading cause of mortality and morbidity in patients with diabetes. It is the single major cause of renal failure in many countries.

Diabetic Nephropathy
This complication reflects a complex pathophysiology, whereby various genetic and environmental factors determine susceptibility and progression to end-stage renal disease. End-stage renal disease (ESRD) due to diabetes has been estimated to be 30-47% of all incident cases worldwide. Disparities in the incidence of ESRD from diabetes among ethnic groups have existed for many years, but the magnitude has been increasing. The World Health Organization (WHO) has estimated that there are currently 346 million people affected by diabetes worldwide and anticipates that diabetes-related deaths would double by 2030.



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