The
ability of Hsp90 to activate a disparate clientele implicates this chaperone in
diverse biological processes. To accommodate such varied roles, Hsp90 requiresa variety of regulatory mechanisms that are coordinated in order to modulate
its activity appropriately.
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| Hsp90 |
Amongst
these, the master-regulator heat shock factor 1 (HSF1) is critically important
in upregulating Hsp90 during stress, but is also responsible, through
interaction with specific transcription factors (such as STAT1 and Strap/p300)
for the integration of a variety of biological signals that ultimately modulate
Hsp90 expression. Additionally, transcription factors, such as STAT1, STAT3
(including STAT1-STAT3 oligomers), NF-IL6, and NF-kB, are known to influence
Hsp90 expression directly.
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