Heart failure is the number one killer of men
and women in the United States. Despite spending more than $35 billion annually
on the treatment of heart disease in the US, the number of patients progressingto heart failure is increasing. Currently, there is no strategy to reverse or
halt the progression of heart failure.
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| Ischemic Heart Failure |
Over the past few years, stem cell
transplantation has risen as a new therapeutic strategy for treating IHF. A
large number of preclinical as well as clinical studies were performed using adult
bone marrow-derived cells with mixed results. The majority of the studies
showed modest improvement in cardiac function in IHF. Among the studies tested
adult cell types, cardiac c-Kit+ progenitor cells proved to be potential
candidates as therapeutic agents; however, the low cardiogenic potential of
transplanted adult cells and c-Kit+ cells may present a major obstacle.
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