Vitiligo is a pigmentary
disorder that affects 0.38-1.13% of the population in different regions of the
world. The pathogenesis of vitiligo is still unknown, but genetic and
immunological factors have an important role in the origin of vitiligo.
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| Vitiligo |
Human leukocyte antigen
(HLA) molecules perform a crucial function in the regulation of the immune response.The
human leucocyte antigen (HLA) is now recognized as a major contributing factor
for susceptibility to a variety of autoimmune diseases, and numerous
associations with vitiligo have focused on the HLA system. Most of them
reported multiple HLA class II alleles to be associated with vitiligo in
different populations; however, a few studies had consistent association
evidence, which might be explained by weak genetic effects or complex gene-gene
or gene environmental interactions, population stratification or genetic
differences between populations.
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